Gimeracil

产品名称：

103766-25-2
Gimeracil
5-Chloropyridine-2,4-diol
5-chloro-4-hydroxypyridin-2(1H)-one
CDHP
Gimestat

产品介绍：

产品说明

生化/生理作用

Gimeracil (5-chloro-2, 4-dihydroxypyridine) is an orally active inhibitor against dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine and the chemotherapeutic drug 5-fluorouracil (5FU). Gimeracil is shown to exhibit cancer-radiosensitizing efficacy in cultures in vitro (1 mM) and in mice in vivo (2.5-25 mg/kg, p.o.) in a DPYD-dependent manner via partial suppression of DNA repair by homologous recombination (HR).

基本信息

经验(实验)分子式	C₅H₄ClNO₂
分子量	145.54
MDL编号	MFCD08458352
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to brown
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
InChI	1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9)
InChI key	ZPLQIPFOCGIIHV-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3