IRE1α Kinase-Inhibiting RNase Attenuator 8

产品名称：

1630086-20-2
KIRA8
AMG18
2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide
AMG 18
IRE1α Kinase-Inhibiting RNase Attenuator 8
(S)-2-Chloro-N-(6-methyl-5-((3-(2-(piperidin-3-ylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-yl)benzenesulfonamide
AMG-18
Compound 18

产品介绍：

产品说明

生化/生理作用

KIRA8 is an ATP-competitive, potent and selective IRE1α kinase inhibitor (IRE1α/β K_i = 2/120 nM) that attenuates IRE1α endonuclease activity (IRE1α/β IC₅₀ = 5/55 nM) with good kinome selectivity. KIRA8 inhibits thapsigargin-induced UPR (IC₅₀ = 99 nM; HT1080 XBP1-Luc cells) and shows therapeutic efficacy in murine models of type 1 diabetes (T1D), pulmonary fibrosis, multiple myeloma (MM), and pancreatic neuroendocrine tumors (PanNET) in vivo (30-50 mg/kg/day i.p.).

基本信息

经验(实验)分子式	C₃₁H₂₉ClN₆O₃S
分子量	601.12
MDL编号	MFCD28404657

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3