Lomeguatrib

产品名称：

192441-08-0
Lomeguatrib
O6-(4-bromothenyl)guanine
2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Lomeguatrib is a highly potent inactivator of O(6)-methylguanine-DNA methyltransferase (MGMT), a DNA repair protein which can confer resistance to some cancer chemotherapeutics, in particular the DNA alkylating agents such as Temozolomide, DTIC, Carmustine, etc. Lomeguatrib is a highly potent inactivator of MGMT and can be used to further investigate mechanisms of resistance. It is a potent irreversible inactivator of all mammalian O6-alkylguanine-DNA-alkyltransferases, so far tested with nanomolar activity in vitro and in vivo.

基本信息

经验(实验)分子式	C₁₀H₈BrN₅OS
分子量	326.17
MDL编号	MFCD23703756
PubChem化学物质编号	329825566
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 10 mg/mL, clear
储存温度	room temp
SMILES string	Nc1nc(OCc2cc(Br)cs2)c3nc[nH]c3n1
InChI	1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)
InChI key	JUJPKFNFCWJBCX-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable