RRD-251 hydrochloride

产品名称：

72214-67-6
RRD-251 hydrochloride
(2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride
S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride
Rb/Raf-1 disruptor 251 hydrochloride
2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.

基本信息

经验(实验)分子式	C₈H₈Cl₂N₂S· HCl
分子量	271.59
MDL编号	MFCD00035047
PubChem化学物质编号	329823647

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to off-white
溶解性	DMSO: >10 mg/mL H₂O: >2 mg/mL
储存温度	room temp
SMILES string	Cl.NC(=N)SCc1ccc(Cl)cc1Cl
InChI	1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(7(10)3-6)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
InChI key	COMNQRICZGJVLE-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3