SM-19712 hydrate

产品名称：

194542-56-8
SM-19712 hydrate
4-Chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl]benzenesulfonamide sodium salt hydrate

产品介绍：

产品说明

应用

SM-19712 hydrate was used in studies to determine the effectiveness of ECE inhibition as a treatment option for Alzheimer′s disease.

包装

5, 25 mg in glass bottle

生化/生理作用

SM-19712 a sulfonylureid-pyrazole derivative is a potent and selective inhibitor of endothelin converting enzyme (ECE). It attenuates the effects of ischemic acute renal failure and reduces the inflammation, tissue injury and vasoconstriction induced by dextran sodium sulfate in mouse colon.
Nonpeptide, potent and selective endothelin converting enzyme inhibitor.

基本信息

经验(实验)分子式	C₁₈H₁₃ClN₅NaO₃S · xH₂O
分子量	437.84 (anhydrous basis)
MDL编号	MFCD06798351
PubChem化学物质编号	329824532
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	off-white to light brown
溶解性	DMSO: ≥20 mg/mL H₂O: ≥20 mg/mL
储存温度	2-8℃
SMILES string	ClC1=CC=C(S(N(C(NC2=C(C#N)C(C)=NN2C3=CC=CC=C3)=O)[Na])(=O)=O)C=C1
InChI	1S/C12H10ClN5O3S.Na.H2O/c1-7-10(6-14)11(17-16-7)15-12(19)18-22(20,21)9-4-2-8(13)3-5-9;;/h2-5H,1H3,(H3,15,16,17,18,19);;1H2/q;+1;/p-1
InChI key	HLHPDQXMLDUDQV-UHFFFAOYSA-M

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves