(1E)-N-(1-Methyl-1H-benzoimidazol-2-yl)-N′-(1-pyridin-2-yl-ethylidene)-hydrazine

产品名称：

380537-35-9
SI-2
(1E)-1-(2-Pyridinyl)ethanone 1-(1-methyl-1H-benzoimidazol-2-yl)-hydrazone
(1E)-N-(1-Methyl-1H-benzoimidazol-2-yl)-N′-(1-pyridin-2-yl-ethylidene)-hydrazine

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

SI-2 targets the receptor-interacting domain (RID) of steroid receptor coactivators (SRCs) and suppresses cellular transcriptional activity (Effec. conc. >/= 5 nM in cell-based SRC-1, SRC-2, and SRC-3 reporter assays) by downregulating SRCs protein, but not transcript level (Effec. conc. >/= 12.5 nM against SRC-3, >/= 25 nM against SRC-1 and SCR-2 in MDA-MB-468 culture). SI-2 is cytotoxic to breast cancer cultures (IC₅₀ = 1.5 nM/BT-474, 3.4 nM/MDA-MB-468, 22 nM/MCF-7), but not to normal hepatocytes even at 500 nM concentration. SI-2 is reported to be orally available in mice and, when administered intraperitoneally (2 mg/kg b.i.d.), effectively suppress MDA-MB-468-derived tumor expansion in mice in vivowith good pharmacokinetics (C_max = 30 μM, t_max = 0.25 h, t_1/2 = 1.0 h; 20 mg/kg i.p.) and no apparent adverse effects to the animals.

基本信息

经验(实验)分子式	C₁₅H₁₅N₅
分子量	265.31

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	, light yellow to dark orange
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃
SMILES string	C/C(C1=CC=CC=N1)=N\NC2=NC3=C(C=CC=C3)N2C

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319
预防措施声明	P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable