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Thiophene-4

品牌
Sigma-Aldrich
CAS
551907-64-3
货号
SML1151
包装型号
规格纯度
≥98% (HPLC)
参考价格
5627.07 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
551907-64-3
Thiophene-4
TP4
5-(Aminocarbonyl)-4-methyl-2-[(pentafluorobenzoyl)amino]-3-thiophenecarboxylic acid ethyl ester
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Thiophene-4 (TP4) is an inhibitor of polyketide synthase 13 (Pks13), which plays a critical role in the biosynthesis of mycolic acid, an essential component of the cell wall in M. tuberculosis, and is a potential new target for tuberculosis treatment. TP4 inhibits FadD32-dependent loading of the mycolic acid precursor meromycoloyl chain onto acyl carrier protein (ACP) domains located at the N terminus of Pks13, preventing synthesis of mycolic acid and resulting in mycobacterial cell death. TP4 bacteriosidal activity is equivalent to treatment with the first-line drug isoniazid, and enhances its activity, but is less likely to cause resistance. The minimal inhibitory concentration (MIC) values of TP4 against drug-susceptible multidrug-resistant M. tuberculosis strains is approximately 500 nM.

基本信息

经验(实验)分子式C16H11F5N2O4S
分子量422.33
MDL编号MFCD01353700
PubChem化学物质编号329825684
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 20 mg/mL, clear
储存温度2-8℃
SMILES stringNC(C1=C(C)C(C(OCC)=O)=C(NC(C2=C(F)C(F)=C(F)C(F)=C2F)=O)S1)=O
InChI1S/C16H11F5N2O4S/c1-3-27-16(26)5-4(2)12(13(22)24)28-15(5)23-14(25)6-7(17)9(19)11(21)10(20)8(6)18/h3H2,1-2H3,(H2,22,24)(H,23,25)
InChI keyANCBHJKEYPZCTE-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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