产品说明
应用
3-Ethoxy-5,6-dibromosalicylaldehyde was used to study modulation of autophagy, JNK activation and NF-κB-mediated inflammation.
包装
5, 25 mg in glass bottle
生化/生理作用
3-Ethoxy-5,6-dibromosalicylaldehyde is a non-competitive inhibitor of Inositol-requiring enzyme 1 (IRE1). It inhibits XBP-1 splicing induced pharmacologically in human cells. 3-Ethoxy-5,6-dibromosalicylaldehyde potently inhibits the endoribonuclease of IRE1 but does not inhibit RNases A, T1, or L.
基本信息
| 经验(实验)分子式 | C9H8Br2O3 |
| 分子量 | 323.97 |
| MDL编号 | MFCD00297095 |
| PubChem化学物质编号 | 329825197 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | powder |
| 储存条件 | desiccated |
| 颜色 | yellow |
| 溶解性 | DMSO: ≥15 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | CCOc1cc(Br)c(Br)c(C=O)c1O |
| InChI | 1S/C9H8Br2O3/c1-2-14-7-3-6(10)8(11)5(4-12)9(7)13/h3-4,13H,2H2,1H3 |
| InChI key | MZAISYPWQNBWED-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 - H317 |
| 预防措施声明 | P280 - P301 + P312 + P330 - P302 + P352 |
| 危险分类 | Acute Tox. 4 Oral - Skin Sens. 1 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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