AEM1

产品名称：

1030123-90-0
AEM1
N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidin-4-amine
ARE expression modulator 1

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

AEM1 (ARE expression modulator 1) is also a selective inhibitor of sirtuin 2, which is a protein deacetylase mediated by NAD⁺. Sirtuin 2 supports tumor cell proliferation, thus its inhibition stimulates cell death in tumors.
AEM1 is a potent inhibitor of deregulated Nrf2 transcriptional activity. AEM1 broadly decreases the expression of NRF2 controlled genes and sensitizes A549 cells to various chemotherapeutic agents.

基本信息

经验(实验)分子式	C₂₀H₁₄FN₃O₂S
分子量	379.41

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to light brown
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable