产品说明
一般描述
ABT-418 is an α4β2 agonist of nicotinic receptors.
应用
ABT-418 hydrochloride has been used as a nicotinic acetylcholine receptor (nAChR) agonist to test its effect on spatial memory improvement in attention deficit hyperactivity disorder (ADHD) rat model
ABT-418 [(S)-3-methyl-5-(1 methyl-2-pyrrolidinyl)isoxazole hydrochloride] is a novel neuronal nicotinic acetylcholine receptor (nAChR) ligand with cognitive enhancing and anxiolytic-like activity 3- to 10-fold more potent than (-)-nicotine in rodents. ABT-418 hydrochloride has been used to study new therapeutic approaches for the treatment of Alzheimer′s disease.
包装
5, 25 mg in glass bottle
生化/生理作用
Neuronal nicotinic acetylcholine receptor agonist with cognition enhancing and anxiolytic activities.
特点和优势
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
法律信息
Subject to U.S. Patent No. 5409946 and sold under license from Abbott Laboratories.
基本信息
| 经验(实验)分子式 | C9H14N2O · HCl |
| 分子量 | 202.68 |
| MDL编号 | MFCD11045960 |
| PubChem化学物质编号 | 24724395 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 储存条件 | desiccated |
| 溶解性 | H2O: soluble 15 mg/mL |
| 创始人 | Abbott |
| SMILES string | Cl.CN1CCC[C@H]1c2cc(C)no2 |
| InChI | 1S/C9H14N2O.ClH/c1-7-6-9(12-10-7)8-4-3-5-11(8)2;/h6,8H,3-5H2,1-2H3;1H/t8-;/m0./s1 |
| InChI key | VOXHERKWAIEJQF-QRPNPIFTSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H300 + H310 + H330 |
| 预防措施声明 | P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310 |
| 危险分类 | Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral |
| 储存分类代码 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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