AC1903

产品名称：

831234-13-0
AC1903
N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine

产品介绍：

产品说明

应用

AC1903 has been used as a drug candidate in a high-throughput agar colony formation assay to identify its therapeutic efficiency against medulloblastoma.

生化/生理作用

AC1903 is a specific inhibitor of TRPC5, the transient receptor potential canonical channel 5, a Ca²⁺permeable nonselective cation channel highly expressed in brain and kidney. AC1903 did not inhibit TRPC4 or TRPC6 currents and showed no off-target effects in kinase profiling assays. It specifically blocked TRPC5 channel activity in glomeruli of proteinuric rats, suppressed severe proteinuria, showing a therapeutic benefit in a rat model of hypertensive proteinuric kidney disease.
Chronic administration of AC1903 averts the loss of podocytes in a transgenic rat model of focal segmental glomerulosclerosis (FSGS).

基本信息

经验(实验)分子式	C₁₉H₁₇N₃O
分子量	303.36
MDL编号	MFCD06609959
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	C12=CC=CC=C1N=C(NCC3=CC=CO3)N2CC4=CC=CC=C4

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable