AZD0530

产品名称：

379231-04-6
AZD0530
7-[2-[4-Methylpiperazin-1-yl]ethoxy]-5-[[tetrahydropyran-4-yl]oxy]-4-[[6-chloro-2,3-methylenedioxyphenyl]amino]quinazoline
4-(6-Chloro-2,3-methylenedioxyanilino)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-tetrahydropyran-4-yloxyquinazoline
AZD-0530
AZD 0530
N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
Saracatinib

产品介绍：

产品说明

生化/生理作用

AZD0530 is an orally active, potent tyrosine kinase inhibitor against Src family kinases (IC50 = 2.7 nM/c-Src, <4 nM/Lck, 4 nM/c-Yes, 5 nM/Lyn, 10 nM/Fyn, 10 nM/Fgr, 11 nM/Blk), v-Abl (IC50 = 30 nM) and EGFR (L861Q/L858R/wt IC50 = 4/5/66 nM). AZD0530 exhibits anti-proliferation activity in cancer cultures (IC50 = 80-700 nM; Src Y530F NIH 3T3, LoVo, K562, PC-9, SW 403, PC-3) and shows efficacy against several human tumor xenograft growth in mice in vivo (6.25-50 mg/kg/day p.o.; MDA-MB-231, AsPc-1, Calu-6, BT474C).

基本信息

经验(实验)分子式	C₂₇H₃₂ClN₅O₅
分子量	542.03
MDL编号	MFCD09832698

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable