Anle138b

产品名称：

882697-00-9
Anle138b
Anle 138b
3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole
5-(1,3-Benzodioxol-5-yl)-3-(3-bromophenyl)-1H-pyrazole
CID 44608289

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Anle138b is a fluorescent inhibitor of α-synuclein and prion-protein (PrPSc) aggregation that reduces the progression of prion and Parkinson′s disease in animal models. Anle138b extends the survival of mice infected with prions. Anle138b strongly inhibits BSE-derived and human prions. The fluorescence strongly increases upon binding with α-synuclein fibrils. Apparently, Anie138b binds to hydrophobic pockets in the fibrils.
Anle138b, an oligomer modulator, inhibits neuronal degeneration. It rescues neurons from the aggregation effects of α-synuclein.

基本信息

经验(实验)分子式	C₁₆H₁₁BrN₂O₂
分子量	343.17
PubChem化学物质编号	329825932
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃
SMILES string	BrC1=CC(C2=CC(C3=CC(OCO4)=C4C=C3)=NN2)=CC=C1
InChI	1S/C16H11BrN2O2/c17-12-3-1-2-10(6-12)13-8-14(19-18-13)11-4-5-15-16(7-11)21-9-20-15/h1-8H,9H2,(H,18,19)
InChI key	RCQIIBJSUWYYFU-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable