产品说明
应用
Aurothioglucose hydrate has been used in redox stress survival assay in human cell lines and for inducing obese phenotype in mice.
包装
5, 25 mg in glass bottle
生化/生理作用
Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC50 approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.
特点和优势
This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
基本信息
| 经验(实验)分子式 | C6H11AuO5S · xH2O |
| 分子量 | 392.18 (anhydrous basis) |
| EC 号 | 235-365-7 |
| PubChem化学物质编号 | 24724383 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥96% (titration) |
| 形式 | powder |
| 储存条件 | desiccated |
| 颜色 | white to beige |
| 溶解性 | H2O: 5 mg/mL, clear |
| 储存温度 | 2-8℃ |
| SMILES string | O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O |
| InChI | 1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1 |
| InChI key | SGVIEHTYEMEDRR-PKXGBZFFSA-M |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H317 - H334 |
| 预防措施声明 | P261 - P280 - P342 + P311 |
| 危险分类 | Resp. Sens. 1 - Skin Sens. 1 |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
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