BAY-294

产品名称：

2244904-69-4
BAY-294
BAY 294
BAY-293 (S)-enantiomer
6,7-Dimethoxy-2-methyl-N-[(S)-1-(4-{2-[(methylamino)methyl]phenyl}thien-2-yl)ethyl]quinazolin-4-amine
BAY293 control
BAY294
BAY 293 control
BAY-293 control
BAY293 (S)-enantiomer
BAY 293 (S)-enantiomer

产品介绍：

产品说明

生化/生理作用

BAY-294 corresponds to the (S)-enantiomer of and the recommended control for the selective SOS1-KRAS interaction inhibitor BAY-293 (IC50 = 2.34 μM/BAY-294 vs. 21 nM/BAY-293; 10 nM hSOS1cat & 5 nM hKRAS G12C). BAY-294 exhibits little potency against SOS1-mediated KRAS activation (IC50 = 3.91 μM/BAY-294 vs. 52 nM/BAY-293; 10 nM SOS1cat & 50 nM wt hKRAS).

基本信息

经验(实验)分子式	C₂₅H₂₈N₄O₂S
分子量	448.58

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D +86.0 to +106.0°, c = 1.0 in DMSO
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
SMILES string	C[C@@H](C1=CC(C2=CC=CC=C2CNC)=CS1)NC3=C4C=C(C(OC)=CC4=NC(C)=N3)OC

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable