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BML-210

品牌
Sigma-Aldrich
CAS
537034-17-6
货号
B8063
规格纯度
≥98% (HPLC), powder
参考价格
1364.72 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
537034-17-6
BML-210
N1-(2-aminophenyl)-N8-phenyl-octanediamide
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

BML-210 is a synthetic benzamide and is a potential tumor inhibitor. It is used as a therapeutic agent to treat promyelocytic leukemia. In human leukemia cell lines (NB4, HL-60, THP-1, and K562), BML-210 modulates histone deacetylase and promotes apoptosis. BML-210 favors frataxin expression in neurodegenerative disease Friedreich′s ataxia (FRDA). It interacts with myocyte enhancer factor-2 (MEF2) via hydrogen-bonding and prevents histone deacetylase 4 (HDAC4) binding.
BML-210 is a histone deacetylase inhibitor. Treatment of A549 cells with BML-210 results in a dose-dependent increase in acetylated histone levels (EC50 = 36 μM). In HeLa extracts, the IC50 for inhibition of HDAC activity is 80 μM.

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式C20H25N3O2
分子量339.43
MDL编号MFCD08062139
PubChem化学物质编号329773304
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to very faintly yellow
溶解性DMSO: >20 mg/mL
储存温度2-8℃
SMILES stringNc1ccccc1NC(=O)CCCCCCC(=O)Nc2ccccc2
InChI1S/C20H25N3O2/c21-17-12-8-9-13-18(17)23-20(25)15-7-2-1-6-14-19(24)22-16-10-4-3-5-11-16/h3-5,8-13H,1-2,6-7,14-15,21H2,(H,22,24)(H,23,25)
InChI keyRFLHBLWLFUFFDZ-UHFFFAOYSA-N

安全信息

危险声明H413
危险分类Aquatic Chronic 4
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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