CGP 52608

产品名称：

87958-67-6
CGP 52608
1-[3-Allyl-4-oxo-thiazolidine-2-ylidene]-4-methyl-thiosemicarbazone
N-Methyl-2-[4-oxo-3-(2-propen-1-yl)-2-thiazolidinylidene]-hydrazinecarbothioamide

产品介绍：

产品说明

应用

CGP 52608 has been used as a RAR related orphan receptor α (RORα) synthetic agonist in THP-1 macrophages, in human monocyte cells THP1 and somatic testicular cells.

包装

5, 25 mg in glass bottle

生化/生理作用

CGP 52608 is a thiazolidine derivative and an antiarthritic compound. It possesses immunostimulatory functionality and elicits antiproliferative effect in colon tumors. It is cytotoxic towards neural cell lines. CGP 52608 induces apoptosis in tumor and also favors G0-G1 cell cycle phase accumulation in neural cell lines.
CGP 52608 is a specific activator of retinoic acid receptor-related orphan receptor α (RORA).

特点和优势

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₈H₁₂N₄OS₂
分子量	244.34
MDL编号	MFCD00942304
PubChem化学物质编号	329775098
NACRES	NA.77

产品性质

质量水平	100
测定	≥98%
形式	solid
溶解性	DMSO: >30 mg/mL H₂O: insoluble
储存温度	−20℃
SMILES string	CNC(=S)N\N=C1/SCC(=O)N1CC=C
InChI	1S/C8H12N4OS2/c1-3-4-12-6(13)5-15-8(12)11-10-7(14)9-2/h3H,1,4-5H2,2H3,(H2,9,10,14)/b11-8-
InChI key	DDYJDIHOSRTMSE-FLIBITNWSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable