FR194921

产品名称：

202646-80-8
FR194921
2-(1-Methyl-4-piperidinyl)-6-[2-phenylpyrazolo-(1,5-a)pyridin-3-yl]-3(2H)-pyridazinone

产品介绍：

产品说明

生化/生理作用

FR194921 is a blood-brain barrier-permeable A1R adenosine receptor antagonist. The measured Ki values of FR194921 for the human adenosine A1 receptors have been in the low nM range with no binding affinity for A2A and A3 receptors up to 1μM. It is orally active and has good bioavailability. FR194921 was used in a recent study to restore auditory cortex plasticity. Paired with sound exposure, FR194921 resulted in cortical map plasticity and improved auditory perception in adult mice.

基本信息

经验(实验)分子式	C₂₃H₂₃N₅O
分子量	385.46
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	CN(CC1)CCC1N2N=C(C=CC2=O)C3=C4N(N=C3C5=CC=CC=C5)C=CC=C4

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3