GRL-0617

产品名称：

1093070-16-6
GRL-0617
GRL0617
5-Amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide
GRL 0617

产品介绍：

产品说明

生化/生理作用

GRL-0617 is a cell penetrant non-cytotoxic and potent inhibitor of the SARS-CoV -2 papain-like protease (SCoV2-PLpro) and SCoV-PLpro. GRL-0617 reversibly binds to SCoV2-PLpro and disrupts its interaction with Interferon-stimulated gene 15 (ISG15). GRL-0617 poorly affects (> 100 μM) the activities of MERS PLpro, a series of cysteine proteases, including the human deubiquitinating enzymes HAUSP, USP18, UCH-L1, UCH-L3, and a papain-like protease (PLP2) from the human coronavirus NL63. GRL-0617 suppress SARS-CoV-2 infection and promote anti-viral immunity.

基本信息

经验(实验)分子式	C₂₀H₂₀N₂O
分子量	304.39
MDL编号	MFCD12547683

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D -72.0 to -82.0°, c = 0.5 in chloroform-d
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable