L-798106

产品名称：

244101-02-8
L-798106
(2E)-N-[(5-bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide

产品介绍：

产品说明

应用

L-798106, a selective prostanoid receptor EP3 antagonist, is used in prostanoid receptor signaling studies that regulate COX-2 levels and the central excitatory effects of PGE(2) on PVN neurons.

包装

5, 25 mg in glass bottle

生化/生理作用

L-798106 was among the first prostanoid receptor EP3-selective antagonists. It has been used in multiple studies to tease out EP3 agonist activity, both in vitro and in vivo. It successfully blocks the actions of sulprostone, an EP3-selective agonist, and it helped show that the vascular contraction effect of PGE₂ is due to its prostanoid EP3 agonist activity.

特点和优势

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式	C₂₇H₂₂BrNO₄S
分子量	536.44
MDL编号	MFCD08272644
PubChem化学物质编号	329817411

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
溶解性	DMSO: >20 mg/mL
创始人	Merck & Co., Inc., Kenilworth, NJ, U.S.
储存温度	2-8℃
SMILES string	COc1ccc(Br)cc1S(=O)(=O)NC(=O)\C=C\c2ccccc2Cc3ccc4ccccc4c3
InChI	1S/C27H22BrNO4S/c1-33-25-14-13-24(28)18-26(25)34(31,32)29-27(30)15-12-21-7-3-5-9-23(21)17-19-10-11-20-6-2-4-8-22(20)16-19/h2-16,18H,17H2,1H3,(H,29,30)/b15-12+
InChI key	ODTKFNUPVBULRJ-NTCAYCPXSA-N

安全信息

危险声明	H413
预防措施声明	P273 - P501
危险分类	Aquatic Chronic 4
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable