ML167

产品名称：

1285702-20-6
ML167
5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol
NCGC00188654
CID 44968231

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC₅₀ of 136 nM for Clk4, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B, and minimal activity against a panel of other kinases tested. The Cdc2-like kinases (Clk′s) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrk′s) are involved in regulation of gene splicing. The Cdc2-like kinases phosphorylate the serine/arginine-rich (SR) proteins, a major component of the spliceosome.

基本信息

经验(实验)分子式	C₁₉H₁₇N₃O₃
分子量	335.36
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	off-white to gray-brown
溶解性	DMSO: 10 mg/mL, clear
储存温度	−20℃

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable