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MDL-860

品牌
Sigma-Aldrich
CAS
78940-62-2
货号
SML2139
规格纯度
≥98% (HPLC)
参考价格
1387.85 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
78940-62-2
MDL-860
2-(3,4-Dichlorophenoxy)-5-nitrobenzonitrile
产品介绍:

产品说明

生化/生理作用

MDL-860 is a 5-nitro-2-phenoxybenzonitrile that exerts broad-spectrum antipicornaviral activity (MIC50 from 0.1-1.5 μg/mL in HeLa cultures) by acting as an irreversible inhibitor against host phosphatidylinositol-4 kinase beta (PI4KB; PtdIns 4-kinase beta; PI4Kbeta; NPIK; PI4K92) via covalent modification of Cys646 located at the bottom of a surface pocket apart from the PI4KB active site. MCL-860 (MIC50 from 0.1-1.5 μg/mL in HeLa cultures). A pleconaril/MDL-860/oxoglaucine consecutive alternating administration (CAA), but not simultaneous daily treatment, is reported to be effective against coxsackievirus B1 infection without the development of drug resistance in newborn mice (75 mg/kg MDL-860 via s.c. every third day on the day following pleconaril and prior to oxoglaucine).

基本信息

经验(实验)分子式C13H6Cl2N2O3
分子量309.10
MDL编号MFCD07832293
NACRESNA.77

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringClC1=CC=C(OC2=CC=C([N+]([O-])=O)C=C2C#N)C=C1Cl
InChI1S/C13H6Cl2N2O3/c14-11-3-2-10(6-12(11)15)20-13-4-1-9(17(18)19)5-8(13)7-16/h1-6H
InChI keyQAYKDRUKUZJJSO-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 + H312
预防措施声明P280 - P301 + P312 + P330
危险分类Acute Tox. 4 Dermal - Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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