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ML133 hydrochloride

ML133 盐酸盐

品牌
Sigma-Aldrich
CAS
1222781-70-5
货号
SML0190
规格纯度
≥95% (HPLC)
参考价格
1476.5 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
1222781-70-5
ML133 hydrochloride
SID 85281105 hydrochloride
1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride
N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride
CID 781301 hydrochloride
VU0404943-1 hydrchloride
ML133 盐酸盐
产品介绍:

产品说明

应用

ML133 hydrochloride has been used as a Kir2.1 blocker to study the regulation of membrane excitability by inward-rectifier potassium channels (Kir2 family) in the dentate gyrus (DG) granule cells. It has also been used to study the effect of Kir2 on cortical neural activity.
ML133 hydrochloride may be used to study cell signaling that involves the function of potassium channels.

包装

5, 25 mg in glass bottle

生化/生理作用

ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式C19H19NO · HCl
分子量313.82
MDL编号MFCD20921521
PubChem化学物质编号329825217
NACRESNA.77

产品性质

质量水平100
测定≥95% (HPLC)
形式powder
颜色 white to tan
溶解性DMSO: ≥10 mg/mL
储存温度2-8℃
SMILES stringCl.COc1ccc(CNCc2cccc3ccccc23)cc1
InChI1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H
InChI keyNGQIBUUFXDPHKT-UHFFFAOYSA-N

安全信息

象形图GHS05GHS07GHS09
警示用语:Danger
危险声明H302 - H315 - H318 - H335 - H400
预防措施声明P273 - P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
危险分类Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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