您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > N2-Ethyl-2′-deoxyguanosine

N2-Ethyl-2′-deoxyguanosine

品牌
Sigma-Aldrich
CAS
101803-03-6
货号
N3289
规格纯度
≥98% (HPLC), solid
参考价格
1698.93 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
101803-03-6
N2-Ethyl-2′-deoxyguanosine
N2-Et-dG
产品介绍:

产品说明

一般描述

N2-Et-dG, an adduct between DNA and the first metabolite of ethanol (acetaldehyde), strongly blocks transcription by RNA polymerases (RNAPs), including mammalian RNAPII and yeast RNAPII, E. coli RNAP, as well as T7 RNAP. All three of the multisubunit RNAPs incorporate a single rNTP residue opposite the N2-Et-dG lesion. The mammalian RNAPII exclusively incorporates cytidine monophosphate (CMP) opposite the N2-Et-dG lesion. The accessory transcription factor TFIIS does not usually act as a lesion bypass factor; instead, it stimulates the polymerase to remove the CMP incorporated opposite the lesion by mammalian RNAPII. N2-Et-dG reduces CTP incorporation by ~1500 fold.

包装

5, 25 mg in glass bottle

基本信息

经验(实验)分子式C12H17N5O4
分子量295.29
MDL编号MFCD01631004
PubChem化学物质编号329818605
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
颜色 white to off-white
溶解性H2O: >5 mg/mL
储存温度2-8℃
SMILES stringCCNC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](CO)O3)C(=O)N1
InChI1S/C12H17N5O4/c1-2-13-12-15-10-9(11(20)16-12)14-5-17(10)8-3-6(19)7(4-18)21-8/h5-8,18-19H,2-4H2,1H3,(H2,13,15,16,20)/t6-,7+,8+/m0/s1
InChI keyVOKQFDULHQUWAV-XLPZGREQSA-N

安全信息

象形图GHS06GHS08
警示用语:Danger
危险声明H300 + H310 + H330 - H351 - H373
预防措施声明P201 - P202 - P260 - P280 - P302 + P352 + P310 - P304 + P340 + P310
危险分类Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Carc. 2 - STOT RE 2
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Sigma-Aldrich

推荐产品