NQ301

产品名称：

130089-98-4
NQ301
2-Chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone
2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione
NQ 301
Compound 211

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice.

基本信息

经验(实验)分子式	C₂₃H₁₉N₃O · HBr
分子量	434.33
MDL编号	MFCD00559986
PubChem化学物质编号	329825795
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	, faint red to dark red
溶解性	DMSO: 10 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O
InChI	1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3
InChI key	LSQZKIQSQHZVQS-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335 - H400
预防措施声明	P273 - P280 - P304 + P340 + P312 - P305 + P351 + P338 - P337 + P313 - P391
危险分类	Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable