RI(dl)-2

产品名称：

1902146-75-1
RI(dl)-2
N-Ethyl-4-(pyrrolo[1,2-a]quinoxalin-4-yl)aniline

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative that selectively inhibits Rad51-mediated D-loop formation (IC₅₀ = 11.1 μM) without affecting its ssDNA-binding activity (IC₅₀ >100 μM). RI(dl)-2 is shown to inhibit DSBs-induced cellular homologous recombination (HR) activity (IC₅₀ = 3.0 μM by HEK293-based DR-GFP reporter assay) by stabilizing nucleoprotein filaments in a nonfunctional state without affecting DNA damage-induced RAD51 nuclear loci formation or stimulating single-strand annealing (SSA) activity.

基本信息

经验(实验)分子式	C₁₉H₁₇N₃ · xC₂HF₃O₂
分子量	287.36 (free base basis)

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	, light orange to dark red
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃
SMILES string	CCNC1=CC=C(C2=NC3=C(N4C2=CC=C4)C=CC=C3)C=C1.FC(F)(C(O)=O)F

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable