PF-9366

产品名称：

72882-78-1
PF-9366
PF9366
7-Chloro-N,N-dimethyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinoline-1-ethanamine
PF 9366

产品介绍：

产品说明

生化/生理作用

PF-9366 is a methionine adenosyltransferase 2A allosteric inhibitor (human Mat2A IC₅₀/K_d = 420 nM/170 nM) whose binding site overlaps with that of the Mat2A regulator, Mat2B. PF-9366 inhibits cellular SAM production in a Mat2B-competitive manner (IC₅₀ post 6-hr treatment = 1.2 μM wihout vs. 0.86 μM with Mat2B knockdown; H520 lung carcinoma cells) without antiproliferation efficacy in cancer cultures due to an induction of Mat2A upregulation upon allosteric inhibition. Similar to Mat2B, PF-9366 allosteric binding alters Mat2A active site, causing increased substrate affinity and decreased enzyme turnover.

法律信息

Sold for research purposes under agreement from Pfizer Inc.

基本信息

经验(实验)分子式	C₂₀H₁₉ClN₄
分子量	350.84
MDL编号	MFCD31630724

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	room temp
SMILES string	ClC(C=C1)=CC(C(C2=CC=CC=C2)=C3)=C1N4C3=NN=C4CCN(C)C

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable