SB-269970 hydrochloride

产品名称：

261901-57-9
SB-269970 hydrochloride
(R)-3-[2-[2-(4-Methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride
SB 269970A

产品介绍：

产品说明

应用

SB-269970 hydrochloride has been used to study the effect of different endotype combination on the activity of the 5-hydroxytryptamine receptor of tall fescue alkaloids. It has also been used to inhibit dopamine receptor signaling, in order to study its role in early hemocyte activation.
SB-269970 was used to study the role of 5-HT₇ receptors in serotonin-induced hypothermia in rodents.⁶

包装

5, 25 mg in glass bottle

生化/生理作用

SB-269970 is an anti-psychotic agent that shows high affinity for 5-HT₇ receptors. It may be effective in treating cognitive disabilities and schizophrenia-like deficits.⁴ SB-269970 desensitizes and decreases the excitatory effects of 5-HT₇ receptors in rat hippocampus.⁵
Selective 5-HT₇ serotonin receptor antagonist.

法律信息

Sold with the permission of GlaxoSmithKline Pharmaceuticals

基本信息

经验(实验)分子式	C₁₈H₂₈N₂O₃S · HCl
分子量	388.95
MDL编号	MFCD03788020
PubChem化学物质编号	24278708
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D 75 to 90°, c = 1.0 in DMSO
储存条件	desiccated
溶解性	H₂O: 10 mg/mL, clear (warmed to 60 ℃)
储存温度	2-8℃
SMILES string	Cl.CC1CCN(CC1)CC[C@H]2CCCN2S(=O)(=O)c3cccc(O)c3
InChI	1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1
InChI key	XQCJOYZLWFNDIO-PKLMIRHRSA-N
Gene Information	human ... HTR7(3363)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)