PYZD-4409

产品名称：

423148-78-1
PYZD-4409
1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

PYZD-4409 inhibts ATP-dependent activation of human ubiquitin activating enzyme E1 with an IC₅₀ of 20 mM. PYZD-4409 induces cell death, and inhbits clonogenic growth of leukemia and myeloma cell lines, and inhibits leukemia xenograft tumor growth in mice.

基本信息

经验(实验)分子式	C₁₄H₇ClFN₃O₅
分子量	351.67
MDL编号	MFCD01828668
PubChem化学物质编号	329825708
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	, white to very dark brown
溶解性	DMSO: 10 mg/mL, clear
储存温度	−20℃
SMILES string	FC1=CC=C(N2C(C(C(N2)=O)=CC3=CC=C([N+]([O-])=O)O3)=O)C=C1Cl
InChI	1S/C14H7ClFN3O5/c15-10-5-7(1-3-11(10)16)18-14(21)9(13(20)17-18)6-8-2-4-12(24-8)19(22)23/h1-6H,(H,17,20)
InChI key	MSYMKEYWUWVZQY-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H315 - H319 - H335
预防措施声明	P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
危险分类	Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable