Sotrastaurin

产品名称：

425637-18-9
Sotrastaurin
3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione
3-(1H-Indol-3-yl)-4-[2-(4-methyl-piperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione
AEB 071
AEB-071
AEB071
NVP-AEB071

产品介绍：

产品说明

生化/生理作用

Sotrastaurin (AEB071) is an orally active, ATP site-targeting, potent and selective protein kinase C (PKC) inhibitor (Ki in nM/isoform = 0.95/α, 0.64/βI, 2.1/δ, 3.2/ε, 1.8/η and 2.2/θ; IC50 = 2.1/α, 2.0/βI, 1.3/δ, 6.2/ε, 6.1/η and 1.0/θ with 10 μM ATP). Sotrastaurin inhibits TCR/CD28-mediated T cell activation in cultures (IC50 = 54 nM by Jurkat IL-2 promoter reporter line) and exhibits in vivo immunosuppressive efficacy in rat models of local graft versus host (GvH) reaction and cardiac transplantation (10 and 30 mg/kg p.o. q.d. or b.i.d.).

基本信息

经验(实验)分子式	C₂₅H₂₂N₆O₂
分子量	438.48
MDL编号	MFCD16038049

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	faint brown to dark red
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
SMILES string	O=C(NC1=O)C(C2=CNC3=C2C=CC=C3)=C1C4=C5C=CC=CC5=NC(N6CCN(CC6)C)=N4