sAJM589

产品名称：

2089-82-9
sAJM589
5-Hydroxybenzo[a]phenazine
Benzo[a]phenazin-5-ol

产品介绍：

产品说明

生化/生理作用

sAJM589 is a Myc inhibitor that disrupts the Myc-Max heterodimer with an IC50 value of 1.8 μM. sAJM589 was shown to suppress cellular proliferation in a variety of MYC-dependent cancer cell line including strong inhibition of Burkitt lymphoma Raji cell line growth. The mechanism of action of sAJM589 is thought to involve increased ubiquitination of Myc by inhibition of Max binding to Myc, leading to proteasome-mediated degradation.

基本信息

经验(实验)分子式	C₁₆H₁₀N₂O
分子量	246.26
MDL编号	MFCD00437759
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	yellow to orange
溶解性	DMSO: 2 mg/mL, clear (warmed)
储存温度	−20℃
SMILES string	OC1=C2C(C=CC=C2)=C3C(N=C(C=CC=C4)C4=N3)=C1

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable