SR144528

产品名称：

192703-06-3
SR144528
SR-144528
5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide

产品介绍：

产品说明

应用

SR144528 has been used as a cannabinoid CB2 receptor antagonist:

to study its blocking effect on the anti-dyskinetic functionality of HU-308
to study its effects on spontaneous excitatory postsynaptic currents (sEPSCs) from the globus pallidus neurons
to analyze its effect on the gastric emptying in rats

包装

5, 25 mg in glass bottle

生化/生理作用

SR144528 is a potent and highly selective cannabinoid CB2 receptor inverse agonist. SR144528 exhibited a Ki of 0.6 nM at CB2 compared to 400 nM at the related CB1 receptor.

基本信息

经验(实验)分子式	C₂₉H₃₄ClN₃O
分子量	476.05
MDL编号	MFCD05662316
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 10 mg/mL, clear
储存温度	−20℃
SMILES string	C[C@]12[C@H](NC(C3=NN(CC4=CC=C(C)C=C4)C(C5=CC=C(Cl)C(C)=C5)=C3)=O)C(C)(C)[C@@H](C2)CC1
InChI	1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22-,27-,29+/m1/s1
InChI key	SUGVYNSRNKFXQM-XRHWURSXSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3