2-(4-Chlorophenyl)-α-2-piperidinyl-4-quinolinemethanol dihydrochloride

产品名称：

5428-80-8
Vacquinol-1 dihydrochloride
NSC13316
2-(4-Chlorophenyl)-α-2-piperidinyl-4-quinolinemethanol dihydrochloride

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Vacquinol-1 (NSC13316) is a brain penetrant inducer of catastrophic vacuolization in glioblastoma cells (GCs). Vacquinol-1 displays high cytotoxicity to GCs; it induces cell death by membrane ruffling, cell rounding, massive macropinocytic vacuole accumulation, ATP depletion, and cytoplasmic membrane rupture of GCs. Vacquinol-1 originally was developed as an antimalarial compound.
Vacquinol-1 dihydrochloride is potentially used as a therapeutic for Glioblastoma multiforme (GBM). This drug is highly stable in vivo, with a half-life in plasma of 52 hour. Vacquinol-1 has high oral bioavailability and good brain penetration.

基本信息

经验(实验)分子式	C₂₁H₂₁ClN₂O · 2HCl
分子量	425.78
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 5 mg/mL, clear (warmed)
储存温度	2-8℃

安全信息

储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable