ABL127

产品名称：

1073529-41-5
ABL127
(3R)-Dimethyl 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylate
(3R)-1,2-Dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine 1,2-dimethyl ester
CID24856225

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). IC50 values were 11.1 nM and 6.4 nM in MDA-MB-231 and HEK 293T cells with no activity detected against >50 other serine hydrolases. PME-1 regulates the methylesterification state of protein phosphatase 2A (PP2A) and is implicated in cancer and neurodegeneration.

基本信息

经验(实验)分子式	C₁₇H₂₀N₂O₅
分子量	332.35
MDL编号	MFCD28053514
PubChem化学物质编号	329825301
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	film
颜色	colorless
溶解性	DMSO: ≥5 mg/mL
储存温度	2-8℃
SMILES string	O=C1[C@](C2=CC=CC=C2)(C3CCCC3)N(C(OC)=O)N1C(OC)=O
InChI	1S/C17H20N2O5/c1-23-15(21)18-14(20)17(13-10-6-7-11-13,19(18)16(22)24-2)12-8-4-3-5-9-12/h3-5,8-9,13H,6-7,10-11H2,1-2H3/t17-/m0/s1
InChI key	ZRHWCAFAIHTQKD-KRWDZBQOSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable