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CGP 57380

品牌
Sigma-Aldrich
CAS
522629-08-9
货号
C0993
包装型号
规格纯度
≥98% (HPLC)
参考价格
2428.75 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
522629-08-9
CGP 57380
CGP57380
N3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine
产品介绍:

产品说明

应用

CGP 57380 has been used:

  • as a mitogen-activated protein kinase-interacting kinase 1 (MNK1) inhibitor to investigate the role of Mnk1 on eukaryotic translation initiation factor 4F (eIF4F) assembly and Newcastle disease virus (NDV) replication in HeLa cells
  • as an MNK1 inhibitor to block eIF4 complex to evaluate the contribution of interferon (IFN-γ) translation during m157- transgenic (Tg) stimulation
  • as a β-catenin nuclear translocation inhibitor to analyze its effects on cytoplasmic and nuclear fractions of cells

包装

5, 25 mg in glass bottle

生化/生理作用

CGP 57380 is a β-catenin nuclear translocation inhibitor, which prevents the proliferation of several cancers. It enhances radiation-induced apoptosis in nasopharyngeal carcinoma (NPC). CGP 57380 upregulates β-catenin in the cytoplasm and inhibits epithelial-mesenchymal transition (EMT).
CGP 57380 is a cell-permeable selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1).

基本信息

经验(实验)分子式C11H9FN6
分子量244.23
MDL编号MFCD03861062
PubChem化学物质编号24724432

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 10 mg/mL, clear
H2O: <2 mg/mL
储存温度2-8℃
SMILES stringNc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12
InChI1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
InChI keyUQPMANVRZYYQMD-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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