NPS2143 hydrochloride

产品名称：

324523-20-8
NPS2143 hydrochloride
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1)
NPS-2143 hydrochloride
SB-262470-A hydrochloride

产品介绍：

产品说明

应用

NPS2143 hydrochloride has been used to study the function of calcium-sensing receptor :

In the regulation of intestinal calcium transport.
In the regulation of local negative feedback of intestinal calcium absorption.
In sensorimotor decision making during development.

包装

5, 25 mg in glass bottle

生化/生理作用

NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.
NPS2143 is a selective calcium-sensing receptor (CaR) antagonist. The compound blocks increases in cytoplasmic calcium concentrations with an IC₅₀ of 43 nM, and stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells over a wide range of extracellular calcuim concentrations.

基本信息

经验(实验)分子式	C₂₄H₂₅ClN₂O₂ · HCl
分子量	445.38
MDL编号	MFCD16038896
PubChem化学物质编号	329825364
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]20/D +20 to +24°, c = 1.0 in methanol
颜色	white to beige
溶解性	DMSO: >10 mg/mL
储存温度	2-8℃
SMILES string	Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N
InChI	1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1
InChI key	ZEBNDUQLNGYBNL-VEIFNGETSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 + H312 + H332 - H410
预防措施声明	P261 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
危险分类	Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable