JNJ7777120

产品名称：

459168-41-3
JNJ7777120
1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methyl-piperazine

产品介绍：

产品说明

应用

JNJ7777120 has been used as a histamine-4 receptor antagonist:

to study its effects on the pro-inflammatory microglia in rats
to study its effects on the Parkinson′s-like pathology in rat brain
to study its effects on the histamine receptor interaction in periodontal ligament fibroblasts (PDLF)

包装

5, 25 mg in glass bottle

生化/生理作用

JNJ7777120 may exhibit neuroprotective effects against ischemic brain damage. It acts as an anti-inflammatory agent to treat inflammatory diseases. JNJ7777120 is observed to reduce colonic injury, cytokine production, and neutrophil infiltration.
JNJ7777120 is a potent, selective non-imidazole H₄ histamine receptor antagonist.

特点和优势

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₁₄H₁₆N₃OCl
分子量	277.75
MDL编号	MFCD04343337
PubChem化学物质编号	329815408
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
颜色	white to off-white
溶解性	DMSO: >20 mg/mL H₂O: insoluble
创始人	Johnson & Johnson
储存温度	room temp
SMILES string	CN1CCN(CC1)C(=O)c2cc3cc(Cl)ccc3[nH]2
InChI	1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
InChI key	HUQJRYMLJBBEDO-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves