产品说明
应用
Triparanol has been used to inhibit cholesterol biosynthesis in lipid rafts1. Triparanol has also been used as a 3β-hydroxysterol-Δ24-reductase inhibitor to study its effect on delayed-rectifier potassium current (Iks) channels2.
包装
5, 25 mg in glass bottle
生化/生理作用
Triparanol is known to repress Hedgehog signaling in cancer cells and can also inhibit tumor growth3.
Desmosterol Delta24 (D24) reductase inhibitor.
制备说明
Triparanol is soluble in DMSO at 20 mg/ml and is also soluble in alcohol. It is slightly soluble in olive oil and is insoluble in water.
其他说明
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T5200.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
基本信息
| 经验(实验)分子式 | C27H32NO2Cl |
| 分子量 | 438.00 |
| EC 号 | 201-115-0 |
| MDL编号 | MFCD00865748 |
| PubChem化学物质编号 | 24724632 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | powder |
| 颜色 | white to off-white |
| mp | 102.9-103.7 ℃ |
| 溶解性 | DMSO: 20 mg/mL H2O: insoluble alcohol: soluble olive oil: slightly soluble |
| 储存温度 | 2-8℃ |
| SMILES string | CCN(CC)CCOc1ccc(cc1)C(O)(Cc2ccc(Cl)cc2)c3ccc(C)cc3 |
| InChI | 1S/C27H32ClNO2/c1-4-29(5-2)18-19-31-26-16-12-24(13-17-26)27(30,23-10-6-21(3)7-11-23)20-22-8-14-25(28)15-9-22/h6-17,30H,4-5,18-20H2,1-3H3 |
| InChI key | SYHDSBBKRLVLFF-UHFFFAOYSA-N |
| Gene Information | human ... DHCR24(1718), EBP(10682) |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H302 - H318 |
| 预防措施声明 | P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310 |
| 危险分类 | Acute Tox. 4 Oral - Eye Dam. 1 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
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