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位置:首页 > 品牌 > Sigma-Aldrich > Anti-IGF-IR (Ab-1) Mouse mAb (αIR3)

Anti-IGF-IR (Ab-1) Mouse mAb (αIR3)

品牌
Sigma-Aldrich
货号
GR11
规格纯度
liquid, clone αIR3, Calbiochem®
参考价格
6694.05 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-IGF-IR (Ab-1) Mouse mAb (αIR3)
Anti-IGF-R, Anti-Insulin-Like Growth Factor Receptor
Anti-Insulin-Like Growth Factor Receptor, Anti-IGF-R
产品介绍:

产品说明

一般描述

This Anti-IGF-IR (Ab-1) Mouse mAb (αIR3) is validated for use in Immunoblotting, IF, IP, Neutralization Studies, Paraffin Sections for the detection of IGF-IR (Ab-1).
Purified mouse monoclonal antibody generated by immunizing SJL mice with the specified immunogen and fusing splenocytes with FO mouse myeloma cells (see application references). Recognizes the ~130 kDa α and the ~90 kDa β subunits of IGF-I receptor.
Recognizes the ~130 kDa α and the ~90 kDa β subunits of IGF-I receptor.

免疫原

partially purified, human placenta IGF-I receptor
Human

包装

100 μg in Plastic ampoule
Please refer to vial label for lot-specific concentration.

应用

Immunoblotting (not recommended)

Immunofluorescence (1-5 µg/ml)

Immunoprecipitation (1-2 µg/sample)

Neutralization Studies (1 µg/ml; use Cat. No. GR11L)

Paraffin Sections (not recommended)

警告

Toxicity: Standard Handling (A)

外形

In 0.05 M sodium phosphate buffer, 0.2% gelatin.

分析说明

Positive Control
HepG2 cells
Negative Control
HS27 cells

其他说明

Roth, R. 1988. Science239, 1269.
Rohlik, Q.T., et al. 1987. Biochem. Biophy Res. Comm.149, 276.
Rosen, O.M., 1987. Science257, 1452.
Rechler, M.M. and Nissley, S.P., 1986. Hormone Res.24, 152.
Ullrich, A., et al. 1986. EMBO J.5, 2503.
Zapf, S. and Froesch, E.R., 1986. Hormone Res.24, 121.
Humbel, R.E., 1984. I. Chemistry; in Li Hormonal proteins and peptides. Vol 12, Chap. 4 (Academic Press, New York).
Kull, F.C., et al. 1983. J. Biol. Chem.258, 6561.
Anti-IGF-I Receptor (Ab-1) Mouse mAb (αIR3) immunoprecipitates the α and β subunits of the IGF-I receptor. Blocks IGF-I binding to its receptor and may bind weakly to the insulin receptor. It also inhibits the growth of MCF-7 cells in culture suggesting the IGF-I receptor may be involved in autocrine regulation of cell growth (see application references). Antibody should be titrated for optimal results in indvidual systems.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

产品性质

质量水平100
生物来源mouse
抗体形式purified antibody
antibody product typeprimary antibodies
克隆αIR3, monoclonal
形式liquid
包含≤0.1% sodium azide as preservative
species reactivityhuman
manufacturer/tradenameCalbiochem®
储存条件do not freeze
同位素/亚型IgG1
运输wet ice
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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