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位置:首页 > 品牌 > Sigma-Aldrich > 2-二环己基膦基-2′,6′-二甲氧基联苯基

SPhos

2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl

品牌
Sigma-Aldrich
CAS
657408-07-6
货号
901906
规格纯度
95%
参考价格
460.05 *本价格含增值税费
促销
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数量
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产品名称:
657408-07-6
SPhos
S Phos
2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl
2-二环己基膦基-2′,6′-二甲氧基联苯基
产品介绍:

产品说明

一般描述

SPhos [2-Dicyclohexylphosphino-2′, 6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.

应用

SPhos may be used as a ligand in the following processes:

  • Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.
  • Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.
  • Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.

Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation
用于 Suzuki-Miyaura 偶联反应的高通用配体;芳基氯、位阻二芳基、杂二芳基化合物。

法律信息

使用涉及的专利号:US 6307087;EP 1097158;JP 5758844;CA 2336691

基本信息

经验(实验)分子式C26H35O2P
分子量410.53
MDL编号MFCD05861611

产品性质

测定95%
形式powder or crystals
reaction suitabilityreaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand
mp164-166 ℃ (lit.)
165.5 ℃
官能团phosphine
SMILES stringCOc1cccc(OC)c1-c2ccccc2P(C3CCCCC3)C4CCCCC4
InChI1S/C26H35O2P/c1-27-23-17-11-18-24(28-2)26(23)22-16-9-10-19-25(22)29(20-12-5-3-6-13-20)21-14-7-4-8-15-21/h9-11,16-21H,3-8,12-15H2,1-2H3
InChI keyVNFWTIYUKDMAOP-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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