产品说明
一般描述
ALK7 (ACVR1C activin A receptor, type IC; ACVRLK4) is a transmembrane type IC receptor serine kinase for activin or activin-like ligands. Activins, are dimeric factors that belong to the TGF-superfamily of signaling proteins. Activins signal through the hetrodimeric complex that includes two type I (I and IB) and two type II (II and IIB) receptors. The type I receptors (i.e. ALK7) contains a Ser/Thr kinase domain in its cytoplasmic domain that is essential for signaling, while the type II are receptors are essential for ligand binding (Harrison, 2004 & Gray, 2000). Receptor activation involves ligand binding to the promiscuous type II receptor that is known to bind to many ligands. This leads to the recruitment of ALK7 and the formation of a stable heterodimer that results in the phosphorylation and activation of ALK7.
特异性
Recognizes ALK7
免疫原
Synthetic peptide designed against the N-terminal region of human ALK7
应用
Anti-ALK7 Antibody is an antibody against ALK7 for use in WB.
Research Category
Signaling
Research Sub Category
Cytokines & Cytokine Receptors
Developmental Signaling
Growth Factors & Receptors
质量
Routinely evaluated by western blot on either human or rat brain lysate
目标描述
55 kDa
外形
Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide.
Affinity purified using immunogen
储存及稳定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
产品性质
生物来源 | rabbit |
质量水平 | 100 |
抗体形式 | affinity purified immunoglobulin |
antibody product type | primary antibodies |
克隆 | polyclonal |
纯化方式 | affinity chromatography |
species reactivity | human, mouse, rat |
manufacturer/tradename | Upstate® |
technique(s) | western blot: suitable |
NCBI登记号 | NP_660302 |
UniProt登记号 | Q8NER5 |
运输 | wet ice |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 2 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich