产品说明

一般描述

Asiatic acid is a naturally occurring pentacyclic triterpenoid, obtained from Centella asiatica.

应用

积雪草酸衍生物合成的起始物料：

• 抗癌药
• 糖原磷酸化酶抑制剂
• 肝保护剂

Asiatic acid has been used in the in vitro study of its cytotoxic potential in glioblastoma cells. It has also been used for the in vivo quantitative analysis of asiatic acid in Centella asiatica L. and in vitro study of enhancement of asiatic acid yield upon using organic elicitors.

包装

10 mg in glass bottle
50 mg in poly bottle

生化/生理作用

Asiatic acid has been reported to exhibit a pernicious effect on glioblastoma, breast, liver, melanoma, and colon cancers and anti-angiogenic activity. Additionally, it can cross the blood-brain barrier and cause apoptosis in human malignant glioma and hepatoma cells. Asiatic acid also effectively inhibits the Ultraviolet A modulated signal transduction pathways and thereby can be used against UVA-induced photoaging of the skin. It has been noted to show antinociceptive and anti-inflammatory properties plus inhibitory effect on neurotoxicity induced by β-amyloid and glutamate.
积雪草酸常用于伤口愈合。积雪草酸具有抗氧化、抗炎和神经保护属性

基本信息

经验(实验)分子式	C30H48O5
分子量	488.70
EC 号	482-720-9
MDL编号	MFCD00238541
PubChem化学物质编号	329770790
NACRES	NA.25

产品性质

质量水平	200
生物来源	Centella asiatica
测定	≥98% (HPLC)
形式	powder
储存条件	protect from light
颜色	white
mp	325-330 ℃ (lit.)
溶解性	methanol: 1 mg/mL, clear, colorless
储存温度	2-8℃
SMILES string	C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
InChI	1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1
InChI key	JXSVIVRDWWRQRT-UYDOISQJSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable