GYKI 52466 hydrochloride

产品名称：

192065-56-8
GYKI 52466 hydrochloride
1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride

产品介绍：

产品说明

应用

GYKI 52466 hydrochloride has been used as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor selective antagonist in cell viability assays to evaluate the specificity of kainate (KA) effect on cerebellar granule cells (CGCs). It has also been used as an AMPA blocker to study the function of glutamate in neuroadapted sindbis virus (NSV) -induced motor neuron death.

包装

10, 25, 100 mg in glass bottle

生化/生理作用

GYKI 52466 serves as an antagonist of several processes, mediated by glutamate.
Selective allosteric AMPA receptor antagonist; anticonvulsant; skeletal muscle relaxant.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法律信息

Sold under exclusive license from the Institute for Drug Research Ltd., Budapest, Hungary.

基本信息

经验(实验)分子式	C₁₇H₁₅N₃O₂ · HCl
分子量	329.78
MDL编号	MFCD00153803
PubChem化学物质编号	24277984
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
颜色	yellow
溶解性	DMSO: 0.39 mg/mL ethanol: 0.4 mg/mL 0.1 M HCl: 0.68 mg/mL methanol: 1 mg/mL H₂O: >10 mg/mL
SMILES string	Cl[H].CC1=NN=C(c2ccc(N)cc2)c3cc4OCOc4cc3C1
InChI	1S/C17H15N3O2.ClH/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11;/h2-5,7-8H,6,9,18H2,1H3;1H
InChI key	RUBSCPARMVJNKX-UHFFFAOYSA-N
Gene Information	human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves