GBR 12935 dihydrochloride

产品名称：

67469-81-2
GBR 12935 dihydrochloride
1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride

产品介绍：

产品说明

应用

GBR 12935 dihydrochloride has been used as a dopamine reuptake inhibitor to study its effects on noradrenergic stimulation in the medial prefrontal cortex of rats (mPFC). It has also been used as a selective dopamine transporter (DAT) inhibitor to study its effects on behavior and neurochemical response in enriched condition (EC) and impoverished condition (IC) rats.

包装

25, 100 mg in poly bottle

生化/生理作用

GBR 12935 inhibits the dopamine and norepinephrine transporters with K_is of 21.5 nM and 225 nM, respectively. It does not inhibit the serotonin transporter (K_i = 6.5 mM). GBR 12935 binds to a nondopaminergic piperazine site in blood platelets and brain that has been identified as cytochrome P450.

特点和优势

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₂₈H₃₄N₂O · 2HCl
分子量	487.50
MDL编号	MFCD00083175
PubChem化学物质编号	24277959
NACRES	NA.77

产品性质

质量水平	200
测定	≥98% (TLC)
形式	powder
颜色	white
溶解性	H₂O: 20 mg/mL (with warming)
SMILES string	Cl[H].Cl[H].C(CN1CCN(CCOC(c2ccccc2)c3ccccc3)CC1)Cc4ccccc4
InChI	1S/C28H34N2O.2ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27;;/h1-9,11-12,14-17,28H,10,13,18-24H2;2*1H
InChI key	NQWRSILGEXNJIT-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)