(±)-<I>trans</I>-3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine hydrochloride

产品名称：

96850-13-4
Indatraline hydrochloride
Lu 19-005
(±)-trans-3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine hydrochloride

产品介绍：

产品说明

应用

Indatraline hydrochloride has been used:

as a competitive inhibitor of 3H-dopamine ([³H]DA) to study its effects on trans-activator of transcription (Tat) protein on cocaine-induced inhibition of uptake of [3H]DA
as a dopamine transport blocker to study its effects on trace amine-associated receptor 1 (TAAR1)-transfected mice cells
as a nonselective monoamine transport inhibitor to study its anti-angiogenic activities in glioblastoma multiforme (GBM)

包装

10, 25, 100 mg in glass bottle

生化/生理作用

Indatraline is a non-selective monoamine transport inhibitor. It inhibits the reuptake of neurotransmitters, such as serotonin, norepinephrine and dopamine. It exhibits anti-depressant and anti-angiogenic effects. Indatraline also plays a role in inducing autophagy.

特点和优势

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法律信息

Sold with the permission of H. Lundbeck A/S.

基本信息

经验(实验)分子式	C₁₆H₁₅Cl₂N · HCl
分子量	328.66
MDL编号	MFCD00083178
PubChem化学物质编号	24277939
NACRES	NA.77

产品性质

质量水平	100
形式	solid
颜色	white
溶解性	H₂O: 2 mg/mL
储存温度	2-8℃
SMILES string	Cl.CN[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc13
InChI	1S/C16H15Cl2N.ClH/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10;/h2-8,13,16,19H,9H2,1H3;1H/t13-,16+;/m0./s1
InChI key	QICQDZXGZOVTEF-MELYUZJYSA-N
Gene Information	human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

安全信息

象形图
警示用语：	Warning
危险声明	H400
预防措施声明	P273
危险分类	Aquatic Acute 1
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Gloves