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Anti-Matrix Metalloproteinase-3, Propeptide Region antibody produced in rabbit

品牌
Sigma-Aldrich
货号
M6053
规格纯度
~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
参考价格
4330.86 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Matrix Metalloproteinase-3, Propeptide Region antibody produced in rabbit
Anti-MMP-3
产品介绍:

产品说明

一般描述

Matrix metalloproteinase-3 (MMP-3) is also known as stromelysin 1 and the gene encoding it is localized on human chromosome 11q22.3.

特异性

Reacts with reduced and to a lesser extent non-reduced MMP-3. The propeptide is shed after activation; therefore, the antibody recognizes the pro-form of MMP-3 and not the active forms. May be used to distinguish the latent from the active form of MMP-3. Recognizes Stromelysin-1 and Stromelysin-2, but not Stromelysin-3 or other MMP family members.

免疫原

synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-3 (stromelysin-1).

生化/生理作用

Matrix metalloproteinase-3 (MMP-3) plays an important role in cartilage degradation. It can act on a large number of substrates like type II, III, IV, IX and X collagens, laminin and fibronectin. MMP-3 can also activate other matrix metalloproteinases like MMP-1,-2 and -13. It has been associated with rheumatoid arthritis.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.

基本信息

MDL编号MFCD03455413
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous glycerol solution
分子量antigen 59 kDa
antigen (pro-form) 57 kDa
species reactivityhuman
浓度~1 mg/mL
technique(s)western blot: 1:1000
UniProt登记号P08254
运输wet ice
储存温度−20℃
Gene Informationhuman ... MMP3(4314)

Sigma-Aldrich

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