(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate

产品名称：

182485-36-5
(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate
TPMPA hydrate

产品介绍：

产品说明

应用

(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate has also been used as γ-aminobutyric acid C (GABAc) blocker in retinal ganglion cells.
TPMA has been used as a GABA_C receptor antagonist to study the role of inner retinal inhibition in midget ganglion cells. TPMPA has also been used to study the role of GABA_C receptor antagonists in suppressing orientation selectivity in ganglion cells.

包装

10, 50 mg in glass bottle

生化/生理作用

TPMPA is a hybrid of isoguvacine and 3-APMPA designed to retain affinity for GABA_C receptors but not to interact with GABA_A or GABA_B receptors. Electrical assays show that TPMPA is a competitive antagonist of cloned human mu 1 GABA_C receptors expressed in Xenopus laevis oocytes (Kb approx. 2 μM). TPMPA is >100-fold weaker as an inhibitor of rat brain GABA_A receptors expressed in oocytes (Kb approx. 320 μM) and has only weak agonist activity on GABA_B receptors assayed in rat hippocampal slices (EC₅₀ approx. 500 μM). TPMP_A may be used to investigate GABA_C receptor function in the outer retina and in any other areas of the nervous system in which these types of receptor are present.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAC Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

制备说明

(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) hydrate is soluble in water at 16 mg/ml, but is insoluble in DMSO.

法律信息

Sold in the USA under exclusive license from the University of California.

基本信息

经验(实验)分子式	C₆H₁₂NO₂P · xH₂O
分子量	161.14 (anhydrous basis)
PubChem化学物质编号	24278172
NACRES	NA.77

产品性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
颜色	white to off-white
溶解性	H₂O: 16 mg/mL DMSO: insoluble
SMILES string	[H]O[H].CP([O-])(=O)C1=CC[NH2+]CC1
InChI	1S/C6H12NO2P.H2O/c1-10(8,9)6-2-4-7-5-3-6;/h2,7H,3-5H2,1H3,(H,8,9);1H2
InChI key	GXVWAQPRAQORGS-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)