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Tyrphostin A9

酪氨酸激酶抑制剂A9

品牌
Sigma-Aldrich
CAS
10537-47-0
货号
T182
规格纯度
solid
参考价格
1099.87 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
10537-47-0
Tyrphostin A9
[[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile
Malonoben
酪氨酸激酶抑制剂A9
产品介绍:

产品说明

应用

Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.

包装

5 mg in glass bottle
25 mg in poly bottle

生化/生理作用

Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor that can induce apoptosis in cancer cells, inhibit the growth of vascular smooth cells and block calcium release-dependent phosphorylations.

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

制备说明

Tyrphostin A9 is soluble in ethanol at 20 mg/ml, in DMSO at a concentration less than 25 mg/ml. It is insoluble in water.

基本信息

经验(实验)分子式C18H22N2O
分子量282.38
MDL编号MFCD00209853
PubChem化学物质编号24278069
NACRESNA.77

产品性质

生物来源synthetic (organic)
质量水平100
测定≥98% (HPLC)
形式solid
颜色 yellow
mp139-140 ℃
溶解性ethanol: 20 mg/mL
DMSO: <25 mg/mL
H2O: insoluble
SMILES stringCC(C)(C)c1cc(\C=C(\C#N)C#N)cc(c1O)C(C)(C)C
InChI1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3
InChI keyMZOPWQKISXCCTP-UHFFFAOYSA-N
Gene Informationhuman ... EGFR(1956), ORAI1(84876), PDGFRA(5156), PDGFRB(5159)
mouse ... Eef2k(13631), Prkaca(18747), Prkca(18750), Src(20779)

安全信息

象形图GHS06
警示用语:Danger
危险声明H301 + H311
预防措施声明P280 - P301 + P310 + P330 - P302 + P352 + P312
危险分类Acute Tox. 3 Dermal - Acute Tox. 3 Oral
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Sigma-Aldrich

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