产品说明
应用
TRAIL human was used to induce cytotoxicity in A549, a human lung carcinoma cell line.
生化/生理作用
Type II transmembrane protein of the TNF superfamily. Ligand for apoptosis-inducing death receptors DR4 and DR5, decoy receptors DcR1 and DcR2, and osteoprotegerin. Approximately 28% amino acid sequence identity to FAS ligand. Human and mouse TRAIL share 65% sequence identity.
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to TNF family. It is present in both soluble as well as membrane-bound form and can induce rapid apoptosis of various transformed cell lines but not the normal cells. Additionally, the product can also induces apoptotic cell death in TRAIL-sensitive U343MGcells.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.
分析说明
Induces cytotoxicity in mouse L-929 cells in the presence of actinomycin D.
基本信息
| MDL编号 | MFCD01867158 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human |
| 重组 | expressed in NSO cells |
| 描述 | N-terminal 6X histidine-tagged extracellular domain |
| 测定 | >97% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 分子量 | 24 kDa by SDS-PAGE predicted mol wt ~21 kDa |
| technique(s) | cell culture | mammalian: suitable |
| 杂质 | endotoxin, tested |
| UniProt登记号 | P50591 |
| 储存温度 | −20℃ |
| Gene Information | human ... TNFSF10(8743) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
