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位置:首页 > 品牌 > Sigma-Aldrich > (1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione

Ailanthone

臭椿酮

品牌
Sigma-Aldrich
CAS
981-15-7
货号
SML2143
规格纯度
≥98% (HPLC)
参考价格
1619.17 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
981-15-7
Ailanthone
13,21-Didehydrochaparrinone
Δ13-Dehydrochaparrinone
(1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione
臭椿酮
产品介绍:

产品说明

生化/生理作用

Ailanthone, natural compound isolated from Ailanthus altissima (Simaroubaceae), is a potent inhibitor of androgen receptor (AR) that blocks activities of full-length AR and AR splice variants. It overcomes MDV3100 (Enzalutamide)-resistance in castration-resistant prostate cancer cell lines. Ailanthone disrupts the interaction between AR and the chaperones HSP90, HSP70, and HSP40, which leads to AR ubiquitination and degradation.

基本信息

经验(实验)分子式C20H24O7
分子量376.40
EC 号683-145-8
NACRESNA.77

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度−20℃
SMILES stringO[C@@H]1C([C@]([C@@]2([C@]3([H])[C@@]1(O)OC2)[C@@](O4)([H])C[C@@]([C@]3(C)[C@@H]5O)([H])C(C)=CC5=O)([H])CC4=O)=C
InChI1S/C20H24O7/c1-8-4-12(21)16(24)18(3)10(8)5-13-19-7-26-20(25,17(18)19)15(23)9(2)11(19)6-14(22)27-13/h4,10-11,13,15-17,23-25H,2,5-7H2,1,3H3/t10-,11-,13+,15+,16+,17+,18+,19+,20-/m0/s1
InChI keyWBBVXGHSWZIJST-RLQYZCPESA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H300
预防措施声明P301 + P330 + P331 + P310
危险分类Acute Tox. 2 Oral
储存分类代码6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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